The rapid antibiotic resistance development has created a major demand for new antimicrobial agents that can combat resistant strains such as methicillin-resistant S. Until a short time ago, the glycopeptide vancomycin was the only therapeutic choice in this situation.
penetration Vancomycin lung
Linezolid concentrations in infected soft tissue and bone following repetitive doses in diabetic patients with bacterial foot infections. This study demonstrated that there is no difference in the pharmacokinetics, based on age or sex and no dose adjustments are needed. Importantly, linezolid demonstrated excellent and complete oral bioavailability that allows ready conversion from intravenous to oral dosing regimens. Linezolid metabolite levels may increase in patients with severe renal impairment [ 24 ].
Vancomycin is indicated for susceptible strains of methicillin-resistant beta-lactam-resistant staphylococci [ 4 ]. Table 1 Approved indications and pharmacokinetic properties of vancomycin, linezolid, tigecycline and daptomycin [ 4 , 25 , 46 , 70 ]. A literature review was conducted to investigate the pharmacokinetics and pulmonary and tissue penetration of vancomycin and linezolid. Pharmacokinetics of unbound linezolid in plasma and tissue interstitium of critically ill patients after multiple dosing using microdialysis.